Topic: The Electrophysiological Correlates of Processing Self- and Externally-Generated Sensations
To interact effectively with the world, the brain must distinguish between self-generated sensations and external ones. This is achieved through an efference copy-based forward model, which sends a copy of the motor command to sensory cortices with a predicted action outcome. Studies show that self-initiated sensations elicit different neural and behavioral responses than externally generated stimuli. In EEG studies, self-generated auditory stimuli produce smaller early ERP components (N1 and P2) than identical external stimuli. Pre-movement neural activity (RP and LRP) may encode the sensory consequences of actions. In four studies Edward examined the neural and behavioral correlates of the forward model mechanism. Study I found that visual N1 and P2 ERP amplitudes were reduced for self-initiated movements, indicating sensory suppression. Study II showed that RP, but not LRP, encoded anticipation of action-effect contingency. MVPA revealed that pre-movement EEG activity predicts action-feedback. Study III demonstrated reduced N1-P2 amplitudes for both active and quick movements compared to passive movements. LRP amplitudes were greater in active and quick conditions. Study IV, involving patients with schizophrenia or schizoaffective disorder (SSD), found reduced N1 and P2 amplitudes, suggesting impaired action-outcome prediction. The thesis provides a detailed understanding of the efference copy mechanism, highlighting sensory suppression, RP encoding higher-level motor preparation, and potential deficits in SSD patients.
Related paper:
Ody, E., Straube, B., He, Y., Kircher, T. (2023). Perception of self- and externally-generated visual stimuli: Evidence from EEG and behaviour. Psychophysiology 60. https://doi.org/10.1111/psyp.14295
https://onlinelibrary.wiley.com/doi/full/10.1111/psyp.14295
Ody, E., Kircher, T., Straube, B., He, Y., (2024). Pre-movement event-related potentials and multivariate pattern of EEG encode action outcome prediction. https://doi.org/10.31234/OSF.IO/FJK4R
https://onlinelibrary.wiley.com/doi/full/10.1002/hbm.26506
Ody, E., Kircher, T., He, Y., & Straube, B. (2023, September 18). Differential effects of self-initiated, externally triggered, and passive movements on action-outcome processing: Insights from sensory and motor-preparatory ERPs. https://doi.org/10.31219/osf.io/h279c
via @OSFramework
Congratulations!!!
Translational Neuroimaging Marburg 