Paper accepted @SchizRes!!! Multimodal Speech-Gesture Training in Patients With Schizophrenia Spectrum Disorder: Effects on Quality of Life and Neural Processing. Congratulations Lydia!

Riedl, L., Nagels, A., Sammer, G., Choudhury, M., Nonnenmann, A., Sütterlin, A., Feise, C., Haslach, M., Bitsch, F., & Straube, B. (accepted). Multimodal Speech-Gesture Training in Patients With Schizophrenia Spectrum Disorder: Effects on Quality of Life and Neural Processing. Schizophrenia Research

Abstract

Dysfunctional social communication is one of the most stable characteristics in patients with schizophrenia that severely affects quality of life. Interpreting abstract speech and in­tegrating nonverbal information is particularly affected.

Considering the difficulty to treat communication dysfunctions with usual intervention, we investigated the possibility to improve quality of life and co-verbal gesture processing in patients with schizophrenia by applying a multimodal speech-gesture (MSG) training.

In the MSG training, we offered eight sessions (60 min each) including perceptive and ex­pressive tasks as well as meta-learning elements and transfer exercises to 29 patients with schizophrenia spectrum disorder (SSD). In a within-group crossover design, patients were randomized to a TAU-first (treatment as usual first, then MSG training) group (N=20) or an MSG-first (MSG training first, then treatment as usual) group (N=9), and were com­pared to healthy controls (N=17). Outcomes were quality of life and related changes in the neural processing of abstract speech-gesture information, which were measured pre-post training through standardized psychological questionnaires and functional Magnetic Reso­nance Imaging, respectively.

Pre-training, patients showed reduced quality of life as compared to controls but improved significantly during the training. Strikingly, this improvement was correlated with neural ac­tivation changes in the middle temporal gyrus for the processing of abstract multimodal content. Improvement during training, self-report measures and ratings of relatives con­firmed the MSG-related changes.

Together, we provide first promising results of a novel multimodal speech-gesture training for patients with schizophrenia. We could link training induced changes in speech-gesture processing to changes in quality of life, demonstrating the relevance of intact communica­tion skills and gesture processing for well-being.

See preprint: https://psyarxiv.com/a8wn4/


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