In addition to clinically relevant differences in BOLD amplitude, differences in connectivity can be observed in patients with mental disorders, which could be explained by dysfunctional processing. In the TNM-lab functional connectivity, as indication of successful information flow between brain regions, is considered a relevant marker of dysfunctional processing. For example, a dysfunctional fronto-temporal connectivity could explain dysfunctions in patients with schizophrenia for the processing of gestures in an abstract sentence context (Straube et al., 2014).
Another clinically relevant example suggests that a dysfunctional coupling between anterior cingulate cortex and the amygdala is related to non-response in a cognitive behavioral therapy (Lueken et al., 2013).
Lueken, U., Straube, B., Konrad, C., Wittchen, H.-U., Ströhle, A., Wittmann, A., … Kircher, T. (2013). Neural Substrates of Treatment Response to Cognitive-Behavioral Therapy in Panic Disorder With Agoraphobia. American Journal of Psychiatry, 170(11), 1345–55. http://doi.org/10.1176/appi.ajp.2013.12111484
Straube, B., Green, A., Sass, K., & Kircher, T. (2014). Superior Temporal Sulcus Disconnectivity During Processing of Metaphoric Gestures in Schizophrenia. Schizophrenia Bulletin, 40(4), 936–944. http://doi.org/10.1093/schbul/sbt110
Straube, B., Wroblewski, A., Jansen, A., & He, Y. (2018). The connectivity signature of co-speech gesture integration: The superior temporal sulcus modulates connectivity between areas related to visual gesture and auditory speech processing. NeuroImage, 181(2018), 539–549. https://doi.org/10.1016/J.NEUROIMAGE.2018.07.037
Bitsch, F., Berger, P., Nagels, A., Falkenberg, I., & Straube, B. (2018). Impaired right temporo-parietal junction – hippocampus connectivity in schizophrenia and its relevance for representing other minds. Schizophrenia Bulletin