PROTECT-AD

Providing Tools for Effective Care and Treatment of Anxiety Disorders (AD)

Funding: BMBF


The PROTECT-AD project aims at improving psychotherapeutic treatment of anxiety disorders by comparing intensified psychological intervention (IPI) with treatment as usual (TAU). Specifically we investigate (neuro-)biological mechanisms of learning during fear conditioning and extinction as well as dysfunctional processes in patients suffering from anxiety disorders. In our multi-centre project data from 720 patients and 150 healthy control subjects are acquired in Dresden, Berlin, Greifswald, Münster, Bochum, Würzburg and Marburg. As Marburg is the coordination centre for fMRI (subproject P4), we are responsible for supervising and analysing the neuroimaging data.

PROTECT-AD

Abb. Examples of our research regarding the neural correlates of psychotherapy (according to Yang et al., 2014).


Who’s working on PROTECT-AD P4?

Principal investigator: Benjamin Straube

PhD students:  Isabelle Caroline Ridderbusch, Adrian Wroblewski, Yunbo Yang

Medical students: Denis CanaStefanie Morlock


Further information

PROTECT-AD

BMBF


Cooperations regarding fear conditioning and extinction

DFG-funded-research-network: EIFEL-ROF


Related publications

Heinig, I., Pitting, A., Richter, J., Hummel, K., Alt, I., Dickhover, K., Gamer, J., Hollandt, M., Koelkebeck, K., Maenz, A., Tennie, S., Totzeck, C., Yang, Y., Arolt, V., Deckert, J., Domsche, K., Fydrich, T., Hamm, A., Hoyer, J., Kircher, T., Lueken, U., Margraf, J., Neudeck, P., Pauli, P., Rief, W., Schneider, S., Straube, B., Ströhle, A., & Wittchen, H-U. (accepted). Optimising Exposure-Based CBT for Anxiety Disorders via Enhanced Extinction: Design and Methods of a Multicentre Randomised Clinical Trial. International Journal of Methods in Psychiatric Research. IF: 2.857

Kunas, S. L., Yang, Y., Straube, B., Kircher, T., Gerlach, A. L., Pfleiderer, B., Arolt, V., Wittmann, A., Stroehle, A., Wittchen, H.-U., & Lueken, U. (2018). The impact of depressive comorbidity on neural plasticity following cognitive-behavioral therapy in panic disorder with agoraphobia. Journal of Affective Disorders. https://doi.org/10.1016/J.JAD.2018.11.026 IF: 3.786

Sundermann, B., Bode, J., Lueken, U., Westphal, D., Gerlach, A. L., Straube, B., … Pfleiderer, B. (2017). Support Vector Machine Analysis of Functional Magnetic Resonance Imaging of Interoception Does Not Reliably Predict Individual Outcomes of Cognitive Behavioral Therapy in Panic Disorder with Agoraphobia. Frontiers in Psychiatry, 8, 99. http://doi.org/10.3389/fpsyt.2017.00099

Ridderbusch, I.C.*, Richter, J., Yang, Y., Hoefler, M., Weber, H., Reif, A., Hamm, A., Pané-Farré C.A., Gerlach, A.L., Stroehle, A., Pfleiderer, B., Arolt, V., Wittchen, H.-U., Gloster, A., Lang, T., Helbig-Lang, S., Fehm, L., Pauli, P., Kircher, T., Lueken, U.§, & Straube, B.§ (accepted). Association of rs7688285 allelic variation coding for GLRB with fear reactivity and exposure-based therapy in patients with panic disorder and agoraphobia. European Neuropsychopharmacology. IF: 4.468

Seeger, F., Yang, Y., Straube, B., Kircher, T., Höfler, M., Wittchen, H.-U., Ströhle, A., Wittmann, A., Gerlach, A.L., Pfleiderer, B., Arolt, V., Hamm, A., Lang, T., Alpers, G.W., Fydrich, T., & Lueken, U. (accepted) Clinical and neurofunctional substrates of cognitive behavioral therapy on secondary social anxiety disorder in primary panic disorder: a longitudinal fMRI study. Psychotherapy & Psychosomatics (Letter to the Editor), IF: 13.122

Wittmann, A., Schlagenhauf, F., Guhn, A., Lueken, U., Elle, M., Stoy, M., Liebscher, C., Bermpohl, F., Fydrich, T., Pfleiderer, B., Bruhn, H., Gerlach, A.L., Straube, B., Wittchen, H.-U., Arolt, V., Heinz, A., Kircher, T., & Ströhle, A. (2018). Effects of Cognitive Behavioral Therapy on Neural Processing of Agoraphobia-Specific Stimuli in Panic Disorder and Agoraphobia. Psychotherapy and Psychosomatics. https://doi.org/10.1159/000493146 IF: 13.122

Yang, Y., Lueken, U., Wittmann, A., Holtz, K., Kleint, N.I., Herrmann, M.J., Sass, K., Jansen, A., Konrad, C., Ströhle, A., Pfleiderer, B., Lotze, M., Hamm, A., Deckert, J., Arolt, V., Wittchen, H.-U., Kircher, T., Straube, B. (2016). Neural Correlates of Individual Differences in Anxiety Sensitivity: An fMRI Study using Semantic Priming. Soc. Cogn. Affect. Neurosci. 1245–1254. doi:10.1093/scan/nsw024

Yang, Y., Kircher, T., & Straube, B. (2015). Neurale Korrelate von kognitiver Verhaltenstherapie bei Panikstörung. Zeitschrift Für Psychiatrie, Psychologie Und Psychotherapie, 63(2), 79–87. http://doi.org/10.1024/1661-4747/a000226

Yang, Y., Kircher, T., & Straube, B. (2014). The neural correlates of cognitive behavioral therapy: recent progress in the investigation of patients with panic disorder. Behaviour Research and Therapy, 62, 88–96. http://doi.org/10.1016/j.brat.2014.07.011