We suggest that several major mental disorders can be understood as maladaptation of mechanisms controlling stability and transition. Understanding the transitions between episodes and the processes that cause healthy or disordered states to persist is the key to explaining and diagnosing such disorders.

Mechanisms of stability and transition are central to effective action and interaction. We must constantly adjust our motor system to achieve stable, goal-directed interactions with the outside world. Here, we use motor control as a particularly rich system for probing adaptation processes.

The adaptive Mind

One of the most critical challenges facing any organism is to maintain stability in the face of a dynamic and uncertain world. At the same time, successful behavior also rests crucially on our ability to adapt when circumstances fundamentally change.

The Adaptive Mind is a research cluster that brings together scientists from Experimental Psychology, Clinical Psychology and Artificial Intelligence in order to understand how the human mind successfully adapts to changing conditions, and what happens when these adaptive processes fail.

The TNM Lab is specifically involved in


Prof. Dr. Benjamin Straube (PI)

Dr. Yunbo Yang (staff)

Christina Schmitter (staff)

Lydia Riedl (associate)

Dr. Adrian Wroblewski (associate)

Dr. Yifei He (associate)

Ridderbusch, I. C., Wroblewski, A., Yang, Y., Richter, J., Hollandt, M., Hamm, A. O., … Kircher, T.Straube, B. (2021). Neural adaptation of cingulate and insular activity during delayed fear extinction: A replicable pattern across assessment sites and repeated measurements. NeuroImage, 118157. https://doi.org/https://doi.org/10.1016/j.neuroimage.2021.118157

Wroblewski, A., Hollandt, M., Yang, Y., Ridderbusch, I.C., Pietzner, A., Szeska, C., Lotze, M., Wittchen, H.-U., Heinig, I., Pittig, A., Arolt, V., Koelkebeck, K., Rothkopf, C.A., Adolph, D., Margraf, J., Lueken, U., Pauli, P., Herrmann, M.J., Winkler, M.H., Ströhle, A., Dannlowski, U., Kircher, T., Hamm, A.O., Straube, B.*, Richter, J.*, (accepted). Sometimes I feel the fear of uncertainty: How Intolerance of Uncertainty and Trait Anxiety impact fear acquisition, extinction and the return of fear. International Journal of Psychophysiology; preprint. https://doi.org/10.31234/OSF.IO/PM9Z5 *contributed equally IF: 2.903

Straube, B., Kuehne, H., van Dam, L., Frey, K., van Kemenade, B.M., Kircher, T., & Ried, L. (accepted conference contribution). Speech-gesture mismatch detection in individuals with high vs. low schizotypal traits. International Consortium on Schizotypy Research, ICSR 2022.

Arikan, B. E., Kemenade, B. M. Van, Fiehler, K., Kircher, T., Straube, B., & Drewing, K. (2021). Different contributions of efferent and reafferent feedback to sensorimotor temporal recalibration. Scientific Reports, 1–15. https://doi.org/10.1038/s41598-021-02016-5

Cuevas, P.*, He, Y.*, Steines, M. & Straube, B. (2022). The processing of semantic complexity and co-speech gestures in schizophrenia: a naturalistic, multimodal fMRI study. Schizophrenia Bulletin Open, https://doi.org/10.1093/schizbullopen/sgac026  *contributed equally

Uhlmann, L., Pazen, M., van Kemenade, B., Kircher, T., & Straube, B. (2021). Neural Correlates of Self-other Distinction in Patients with Schizophrenia Spectrum Disorders: The Roles of Agency and Hand Identity. Schizophrenia Bulletin, 1–10. https://doi.org/10.1093/schbul/sbaa186

Schmitter, C.V. & Straube, B. (accepted). The impact of cerebellar transcranial direct current stimulation (tDCS) on sensorimotor and inter-sensory temporal recalibration. Frontiers in Human Neuroscience, section Brain Imaging and Stimulation. IF: 3.473

O’Leary, A., Fernàndez-Castillo, N., Gan, G., Yang, Y., Yotova, A. Y., Kranz, T. M., … Kircher, T. …, Straube, B., … Reif, A. (2022). Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits. Molecular Psychiatry, 1–10. https://doi.org/10.1038

Kavroulakis, E., van Kemenade, B. M., Arikan, B. E., Kircher, T., & Straube, B. (2022). The effect of self-generated versus externally generated actions on timing, duration, and amplitude of blood oxygen level dependent response for visual feedback processing. Human brain mapping, 10.1002/hbm.26053. Advance online publication. https://doi.org/10.1002/hbm.26053 IF: 5.399

Riedl, L., Nagels, A., Sammer, G., Choudhury, M., Nonnenmann, A., Sütterlin, A., Feise, C., Haslach, M., Bitsch, F., & Straube, B. (2022). A Novel Multimodal Speech-Gesture Training and Its Impact on Quality of Life and Neural Processing in Patients With Schizophrenia Spectrum Disorder. A Pilot Randomized Controlled Trial. Schizophrenia Research, 246, 112–125

Lubinus, C., Einhäuser, W., Schiller, F., Kircher, T., Straube, B.* & van Kemenade, B.M.* (2022). Action-based predictions affect visual perception, neural processing, and pupil size, regardless of temporal predictability. NeuroImage, in press. IF: 7.400